Welcome to SSPI

Solid State Pharma Inc. (SSPI) is a crystallization engineering and solid state science company founded on the basis of scientific knowledge, hands-on experience and advanced characterization technologies utilization. SSPI is the partner to pharmaceutical and natural product companies to bring value through understanding the solid state of the drug candidates, extending the patent life of the drug and also developing crystallization processes that will lead to optimal physical properties, morphology and particle size distribution through crystallization engineering.


The majority of pharmaceutical intermediates or APIs exhibit polymorphism. Different polymorphs of a drug can have different solubility, dissolution rate and therefore different bioavailability in the body and ultimately different therapeutic effects. The FDA and other regulatory agencies require all pharmaceutical companies to perform polymorph screening before submitting a new drug application (NDA). Therefore, control of API polymorphism has become a critical part of the drug development. SSPI offers a unique workflow that finds all possible polymorphs and identifies the most viable one for drug development.


In addition to pharmaceuticals, SSPI is involved with natural health products. The use of these products has been steadily increasing in recent years. When natural products are used as or defined as a drug, purification to meet the regulatory requirements becomes mandatory. In many cases the primary purification method is chromatography, which is expensive compared with crystallization techniques. Applying solid state science and crystal engineering, cost effective crystallization procedures could be developed which may significantly reduce the manufacturing costs and make natural products more competitive.