Salt screening is a crucial step in the early phases of development for potential drug candidates, whether for IP protection or to improve upon specific properties. The best time for such screening is pre-GLP Tox batch. By forming a salt of a drug candidate or intermediate, there can be an increase in crystallinity, improved physiochemical properties, and/or an increase in bioavailability. All of our workflows are tailored to the specific molecular structure of the drug candidate.
Through this screening, our ingenious scientists will ensure that the client feels confident moving forward with either the freeform of their drug candidate, or a crystalline salt form. Once the most viable form is chosen, a polymorph screening is recommended to view the polymorphic landscape of the material, and to narrow down the most optimal and reliable process for salt formation.