Salt screening is crucial step in the early phases of development for potential drug candidates, whether for IP protection or to improve upon specific properties. The best time for such screening is pre-GLP Tox batch. By forming a salt of a drug candidate or intermediate, there can be in increase crystallinity, improved physiochemical properties, and/or an increase in bioavailability. All our workflows are tailored to the specific molecular structure of the drug substance.
Through this screening, our ingenious scientists will ensure that the client feels confident moving forward with either the free-form of their drug substance, or a crystalline salt form. Once the most viable form is chosen, a polymorph screening is recommended to view the polymorphic landscape of the material, and to narrow down the most optimal and reliable process for salt formation.